abstract：:The mammalian circadian timing system is affected by aging. Analysis of the suprachiasmatic nucleus (SCN) and of other circadian oscillators reveals age-related changes which are most profound in extra-SCN tissues. Some extra-SCN oscillators appear to stop oscillating in vivo or display altered phase relationships. To...

journal_title：Neurobiology of aging

authors： Davidson AJ,Yamazaki S,Arble DM,Menaker M,Block GD

更新日期：2008-03-01 00:00:00

abstract：:We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independent variables and brain volumes were calculated without correct...

journal_title：Neurobiology of aging

authors： Greenberg DL,Messer DF,Payne ME,Macfall JR,Provenzale JM,Steffens DC,Krishnan RR

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of...

journal_title：Neurobiology of aging

authors： Josephs KA,Whitwell JL,Dickson DW,Boeve BF,Knopman DS,Petersen RC,Parisi JE,Jack CR Jr

更新日期：2008-02-01 00:00:00

abstract：:We evaluated young (3-4 months) and aged (22-24 months) male Sprague-Dawley rats in an attentional set-shifting procedure that assessed reversal, intradimensional shift (IDS), and extradimensional shift (EDS) discrimination learning tasks within one test session. These aspects of discrimination learning are sensitive ...

journal_title：Neurobiology of aging

authors： Rodefer JS,Nguyen TN

更新日期：2008-02-01 00:00:00

abstract：:To investigate whether dramatically waned dentate neurogenesis during aging is linked to diminution in neural stem/progenitor cell (NSC) number, we counted cells immunopositive for Sox-2 (a putative marker of NSCs) in the subgranular zone (SGZ) of young, middle-aged and aged F344 rats. The young SGZ comprised approxim...

journal_title：Neurobiology of aging

authors： Hattiangady B,Shetty AK

更新日期：2008-01-01 00:00:00

abstract：:Cerebral A(1) adenosine receptors (A(1)AR) fulfill important neuromodulatory and homeostatic functions. The present study examines possible age-related A(1)AR changes in living humans by positron emission tomography (PET) and the A(1)AR ligand [(18)F]CPFPX. Thirty-six healthy volunteers aged 22-74 years were included....

journal_title：Neurobiology of aging

authors： Meyer PT,Elmenhorst D,Boy C,Winz O,Matusch A,Zilles K,Bauer A

更新日期：2007-12-01 00:00:00

abstract：:Mortalin is a chaperone protein associated with cell survival, stress response, intracellular trafficking, control of cell proliferation, mitochondrial biogenesis, and cell fate determination. Human APOE targeted replacement (TR) mice have been used to elucidate the role of APOE4 in Alzheimer's disease (AD), since the...

journal_title：Neurobiology of aging

authors： Osorio C,Sullivan PM,He DN,Mace BE,Ervin JF,Strittmatter WJ,Alzate O

更新日期：2007-12-01 00:00:00

abstract：:We evaluated pathomechanisms and systemic manifestations of Alzheimer disease (AD), an aging-related dementing neurodegenerative disorder, by expression profiling. Blood mononuclear cell (BMC) transcriptomes of sporadic AD subjects and aged-matched normal elderly controls (NEC) were compared using the human NIA microa...

journal_title：Neurobiology of aging

authors： Maes OC,Xu S,Yu B,Chertkow HM,Wang E,Schipper HM

更新日期：2007-12-01 00:00:00

abstract：:Stroke is an important risk factor for dementia, but the exact mechanisms involved in cognitive decline remain unclear. In this study, we related baseline MRI brain measures with later cognitive decline. Seventy-nine stroke survivors aged 75+ years without dementia were recruited 3-month post-stroke. They underwent ye...

journal_title：Neurobiology of aging

authors： Firbank MJ,Burton EJ,Barber R,Stephens S,Kenny RA,Ballard C,Kalaria RN,O'Brien JT

更新日期：2007-11-01 00:00:00

abstract：:Event-related fMRI studies have investigated age-related changes in encoding by identifying greater activity for items that are later remembered than for those that are forgotten (difference in memory, or Dm). The present study used hybrid blocked/event-related analyses to distinguish between transient Dm versus susta...

journal_title：Neurobiology of aging

authors： Dennis NA,Daselaar S,Cabeza R

更新日期：2007-11-01 00:00:00

abstract：:Zen meditation, a Buddhist practice centered on attentional and postural self-regulation, has been speculated to bring about beneficial long-term effects for the individual, ranging from stress reduction to improvement of cognitive function. In this study, we examined how the regular practice of meditation may affect ...

journal_title：Neurobiology of aging

authors： Pagnoni G,Cekic M

更新日期：2007-10-01 00:00:00

abstract：:Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...

journal_title：Neurobiology of aging

authors： Kantarci K,Weigand SD,Petersen RC,Boeve BF,Knopman DS,Gunter J,Reyes D,Shiung M,O'Brien PC,Smith GE,Ivnik RJ,Tangalos EG,Jack CR Jr

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether cognitive function in the spectrum of normal aging to Alzheimer's disease is better reflected in MRI or EEG measures, or a combination of both. METHODS:Cognitive functions were tested in 33 elderly subjects: 10 with probable Alzheimer's disease, 11 with mild cognitive impairment and 12...

journal_title：Neurobiology of aging

authors： van der Hiele K,Vein AA,van der Welle A,van der Grond J,Westendorp RG,Bollen EL,van Buchem MA,van Dijk JG,Middelkoop HA

更新日期：2007-09-01 00:00:00

abstract：:This study aimed to investigate cross-sectional and longitudinal changes of regional cerebral blood flow (rCBF) in preclinical dementia using single photon emission computed tomography (SPECT). SPECT and cognitive function were investigated in 39 mild cognitive impairment (MCI) subjects and 20 age-matched controls. Al...

journal_title：Neurobiology of aging

authors： Huang C,Eidelberg D,Habeck C,Moeller J,Svensson L,Tarabula T,Julin P

更新日期：2007-07-01 00:00:00

abstract：:The goals were to investigate implicit learning in mild cognitive impairment (MCI), and to determine the relations of implicit learning systems to apolipoprotein E (ApoE) genotype in healthy controls. Elderly controls grouped by ApoE status (ApoE-e4 allele carriers versus ApoE-e4 allele non-carriers) and MCI patients ...

journal_title：Neurobiology of aging

authors： Negash S,Petersen LE,Geda YE,Knopman DS,Boeve BF,Smith GE,Ivnik RJ,Howard DV,Howard JH Jr,Petersen RC

更新日期：2007-06-01 00:00:00

abstract：:Much experimental evidence suggests that an imbalance in cellular redox status is a major factor in the pathogenesis of Alzheimer's disease (AD). Our previous data showed a marked increase in membrane lipoperoxidation in primary fibroblasts from familial AD (FAD) patients. In the present study, we demonstrate that whe...

journal_title：Neurobiology of aging

authors： Cecchi C,Fiorillo C,Baglioni S,Pensalfini A,Bagnoli S,Nacmias B,Sorbi S,Nosi D,Relini A,Liguri G

更新日期：2007-06-01 00:00:00

abstract：:Eyeblink conditioning is a relatively simple form of associative learning that shows neurobiological and behavioral parallels across several species, including humans. Aged subjects acquire eyeblink conditioning more slowly than young ones. In addition, eyeblink conditioning effectively discriminates patients with Alz...

journal_title：Neurobiology of aging

authors： Rose GM,Ong VS,Woodruff-Pak DS

更新日期：2007-05-01 00:00:00

abstract：:Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Severa...

journal_title：Neurobiology of aging

authors： Bullido MJ,Martínez-García A,Artiga MJ,Aldudo J,Sastre I,Gil P,Coria F,Muñoz DG,Hachinski V,Frank A,Valdivieso F

更新日期：2007-04-01 00:00:00

abstract：:Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the ...

journal_title：Neurobiology of aging

authors： Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM

更新日期：2007-03-01 00:00:00

abstract：:Mutations in the presenilin genes account for the majority of familial Alzheimer disease (FAD) cases. In the present report we demonstrated that the FAD-linked presenilin 2 mutations (PS2 M239I and T122R) alter cystatin C trafficking in mouse primary neurons reducing secretion of its glycosylated form. These mutations...

journal_title：Neurobiology of aging

authors： Ghidoni R,Benussi L,Paterlini A,Missale C,Usardi A,Rossi R,Barbiero L,Spano P,Binetti G

更新日期：2007-03-01 00:00:00

abstract：:The reaction of lysine and arginine residues of proteins with 1,2-dicarbonyl compounds result in the formation of advanced glycation end products (AGEs). Accumulation of AGEs is a characteristic feature of the aging brain and contributes to the development of neurodegenerative diseases such as Alzheimer's disease (AD)...

journal_title：Neurobiology of aging

authors： Kuhla B,Boeck K,Schmidt A,Ogunlade V,Arendt T,Münch G,Lüth HJ

更新日期：2007-01-01 00:00:00

abstract：:Mural cells (smooth muscle cells and pericytes) regulate blood flow and contribute to vessel stability. We examined whether mural cell changes accompany age-related alterations in the microvasculature of the central nervous system. The retinas of young adult and aged Wistar rats were subjected to immunohistofluorescen...

journal_title：Neurobiology of aging

authors： Hughes S,Gardiner T,Hu P,Baxter L,Rosinova E,Chan-Ling T

更新日期：2006-12-01 00:00:00

abstract：:Brain deposits of amyloid beta peptide (Abeta) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Abeta is also present in peripheral blood. Here, we present evidence that circulating Abeta42 is subject to complement C3b-dependent adherence to comple...

journal_title：Neurobiology of aging

authors： Rogers J,Li R,Mastroeni D,Grover A,Leonard B,Ahern G,Cao P,Kolody H,Vedders L,Kolb WP,Sabbagh M

更新日期：2006-12-01 00:00:00

abstract：:At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early neurodegeneration of the dendritic inhibitory interneurons (oriens-lacunosum moleculare, O-LM, an...

journal_title：Neurobiology of aging

authors： Ramos B,Baglietto-Vargas D,del Rio JC,Moreno-Gonzalez I,Santa-Maria C,Jimenez S,Caballero C,Lopez-Tellez JF,Khan ZU,Ruano D,Gutierrez A,Vitorica J

更新日期：2006-11-01 00:00:00

abstract：:Although the ApoE epsilon4 allele is well-established as the most important genetic risk factor for Alzheimer's disease (AD), the effects of this allele on regional brain atrophy in AD patients remain controversial. We performed MRI-based volumetric measurements of the hippocampus and amygdala (normalized to intracran...

journal_title：Neurobiology of aging

authors： Basso M,Gelernter J,Yang J,MacAvoy MG,Varma P,Bronen RA,van Dyck CH

更新日期：2006-10-01 00:00:00

abstract：:Dysfunction of circadian melatonin production by the pineal gland in aged humans and rats is thought to reflect the functional loss of its sympathetic innervation. Our ultrastructural neuropathologic studies of the sympathetic innervation of the pineal gland of aged (24 months old) Fischer-344 and Sprague-Dawley rats ...

journal_title：Neurobiology of aging

authors： Schmidt RE,Dorsey DA,Parvin CA,Beaudet LN

更新日期：2006-10-01 00:00:00

abstract：:Several independent linkage studies have mapped a broad susceptibility region for Alzheimer's disease (AD) on the long arm of chromosome 10. There are several biological candidate genes in this region, including choline acetyltransferase (CHAT). A number of studies have examined the role of CHAT genetic variants with ...

journal_title：Neurobiology of aging

authors： Ozturk A,DeKosky ST,Kamboh MI

更新日期：2006-10-01 00:00:00

abstract：:Transgenic mice expressing mutant forms of both amyloid-beta (Abeta) precursor protein (APP) and presenilin (PS) 2 develop severe brain amyloidosis and cognitive deficits, two pathological hallmarks of Alzheimer's disease (AD). One-year-old APP/PS2 mice with high brain levels of Abeta and abundant Abeta plaques show d...

journal_title：Neurobiology of aging

authors： Carro E,Trejo JL,Gerber A,Loetscher H,Torrado J,Metzger F,Torres-Aleman I

更新日期：2006-09-01 00:00:00

abstract：:Poor cognitive performance of elderly individuals with low educational attainment is often difficult to interpret in dementia evaluation. Lack of education, as well as dementia, is often associated with poor cognitive test performance. To elucidate the underlying structural change of low cognitive performance in elder...

journal_title：Neurobiology of aging

authors： Chey J,Na DG,Tae WS,Ryoo JW,Hong SB

更新日期：2006-09-01 00:00:00

abstract：:Cross-sectional studies have found declines in most measures of oculomotor function in older subjects compared to young controls, but no prior study has followed the same subjects over time. We measured saccade peak velocity, saccade delay time, smooth pursuit, optokinetic nystagmus (OKN), visual-vestibular-ocular-ref...

journal_title：Neurobiology of aging

authors： Kerber KA,Ishiyama GP,Baloh RW

更新日期：2006-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a late-onset and progressive neurodegenerative disorder characterized clinically by memory loss, impairment of other cognitive functions, and changes in behavior and personality. The overall aim of this review is to summarize recent advances in studies of AD progression and the use of anima...

journal_title：Neurobiology of aging

authors： Reddy PH,McWeeney S

更新日期：2006-08-01 00:00:00

abstract：:We investigated whether a 2-month dietary supplementation of antioxidants, in the form of blueberry phytochemicals, could reverse or retard the age-related decline in temporal processing speed observed in the aged rat. To this end, extracellular single unit responses to frequency modulated (FM) sweeps were recorded in...

journal_title：Neurobiology of aging

authors： de Rivera C,Shukitt-Hale B,Joseph JA,Mendelson JR

更新日期：2006-07-01 00:00:00

abstract：:Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in b...

journal_title：Neurobiology of aging

authors： Metastasio A,Rinaldi P,Tarducci R,Mariani E,Feliziani FT,Cherubini A,Pelliccioli GP,Gobbi G,Senin U,Mecocci P

更新日期：2006-07-01 00:00:00

abstract：:Overproduction of amyloid precursor protein (APP) and beta-amyloid likely contribute to neurodegeneration in Alzheimer's disease (AD). In an effort to understand neuronal APP gene regulation, we identified a 52 base element (52sce) immediately downstream from the stop codon that stabilizes APP mRNA. Deletion of this d...

journal_title：Neurobiology of aging

authors： Westmark PR,Shin HC,Westmark CJ,Soltaninassab SR,Reinke EK,Malter JS

更新日期：2006-06-01 00:00:00

abstract：:APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences synaptogenesis. We measured the concentration of two presynaptic proteins, synaptophysin and syntaxin 1, and also postsynaptic density-95 (PSD95), in superior temporal co...

journal_title：Neurobiology of aging

authors： Love S,Siew LK,Dawbarn D,Wilcock GK,Ben-Shlomo Y,Allen SJ

更新日期：2006-06-01 00:00:00

abstract：:We recently, characterized a novel peptide of the egg-laying controlling caudodorsal cells (CDC) of Lymnaea stagnalis. Here, we show that the novel peptide has autoinhibitory actions and its expression is significantly up-regulated in reproductively senescent animals. Intracellular recordings show that when bath-appli...

journal_title：Neurobiology of aging

authors： Jiménez CR,Li KW,Smit AB,Janse C

更新日期：2006-05-01 00:00:00

abstract：:The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this ...

journal_title：Neurobiology of aging

authors： Del Bo R,Scarlato M,Ghezzi S,Martinelli-Boneschi F,Fenoglio C,Galimberti G,Galbiati S,Virgilio R,Galimberti D,Ferrarese C,Scarpini E,Bresolin N,Comi GP

更新日期：2006-05-01 00:00:00

abstract：:We report that a peripheral injection of Escherichia coli produces both anterograde and retrograde amnesia in 24 month old, but not 3 month old rats for memories that depend on the hippocampus, that is, memory of context, contextual fear, and place learning. The anterograde effect was restricted to measures of long-te...

journal_title：Neurobiology of aging

authors： Barrientos RM,Higgins EA,Biedenkapp JC,Sprunger DB,Wright-Hardesty KJ,Watkins LR,Rudy JW,Maier SF

更新日期：2006-05-01 00:00:00

abstract：:Recent findings seem to converge towards a unified hypothesis trying to relate Down's syndrome (DS), trisomy 21 and Alzheimer's disease (AD). The majority of DS individuals develop neuropathological characteristics of AD by the age of 40. Previous cytogenetic studies performed by us showed an increased frequency of an...

journal_title：Neurobiology of aging

authors： Migliore L,Boni G,Bernardini R,Trippi F,Colognato R,Fontana I,Coppedè F,Sbrana I

更新日期：2006-05-01 00:00:00

abstract：:The effects of age, subcortical vascular disease, apolipoprotein E (APOE) epsilon4 allele and hypertension on entorhinal cortex (ERC) and hippocampal atrophy rates were explored in a longitudinal MRI study with 42 cognitively normal (CN) elderly subjects from 58 to 87 years old. The volumes of the ERC, hippocampus, an...

journal_title：Neurobiology of aging

authors： Du AT,Schuff N,Chao LL,Kornak J,Jagust WJ,Kramer JH,Reed BR,Miller BL,Norman D,Chui HC,Weiner MW

更新日期：2006-05-01 00:00:00